/* psma-therapie.de – Patienteninformation
   Farbwelt: warm & ruhig (Creme, Salbeigrün, gedecktes Blau, Amber) */

@font-face{font-family:"SourceSans";src:url("../fonts/source-sans-3-latin-400-normal.woff2") format("woff2");font-weight:400;font-style:normal;font-display:swap}
@font-face{font-family:"SourceSans";src:url("../fonts/source-sans-3-latin-400-italic.woff2") format("woff2");font-weight:400;font-style:italic;font-display:swap}
@font-face{font-family:"SourceSans";src:url("../fonts/source-sans-3-latin-700-normal.woff2") format("woff2");font-weight:700;font-style:normal;font-display:swap}
@font-face{font-family:"SourceSerif";src:url("../fonts/source-serif-4-latin-400-normal.woff2") format("woff2");font-weight:400;font-style:normal;font-display:swap}
@font-face{font-family:"SourceSerif";src:url("../fonts/source-serif-4-latin-600-normal.woff2") format("woff2");font-weight:600;font-style:normal;font-display:swap}

:root{
  --bg:#FAF6EF;
  --bg-soft:#F3EDE2;
  --surface:#FFFDF9;
  --ink:#22303C;
  --ink-soft:#4B5966;
  --line:#E4DACB;
  --sage:#4F7A6D;
  --sage-dark:#3A5F54;
  --sage-light:#E3EDE8;
  --blue:#35557A;
  --blue-light:#E4EBF3;
  --amber:#D99A2B;
  --amber-light:#FBF0D9;
  --terra:#B8704F;
  --terra-light:#F6E6DD;
  --radius:18px;
  --radius-sm:10px;
  --shadow:0 1px 2px rgba(60,45,25,.05),0 8px 24px rgba(60,45,25,.06);
  --maxw:1120px;
  --text:1.1875rem;
  --font:"SourceSans",system-ui,-apple-system,"Segoe UI",Arial,sans-serif;
  --serif:"SourceSerif",Georgia,"Times New Roman",serif;
}
html{font-size:100%;scroll-behavior:smooth}
html.fs-lg{font-size:112.5%}
html.fs-xl{font-size:125%}
html.contrast{--bg:#FFFFFF;--bg-soft:#F2F2F2;--surface:#FFFFFF;--ink:#000;--ink-soft:#1a1a1a;--line:#555;--sage:#1F4D40;--sage-dark:#123329;--blue:#0B2A4F;--sage-light:#EAF2EE;--amber-light:#FFF5DB;--terra:#7A3216}
@media (prefers-reduced-motion:reduce){html{scroll-behavior:auto}*{transition:none!important;animation:none!important}}

*,*::before,*::after{box-sizing:border-box}
body{margin:0;background:var(--bg);color:var(--ink);font-family:var(--font);font-size:var(--text);line-height:1.65;-webkit-font-smoothing:antialiased}
img,svg{max-width:100%;height:auto}
a{color:var(--blue);text-decoration-thickness:1px;text-underline-offset:3px}
a:hover{color:var(--sage-dark)}
:focus-visible{outline:3px solid var(--amber);outline-offset:3px;border-radius:4px}
h1,h2,h3,h4{font-family:var(--serif);font-weight:600;line-height:1.2;color:var(--ink);letter-spacing:-.01em}
h1{font-size:clamp(2rem,4.2vw,3rem);margin:.2em 0 .4em}
h2{font-size:clamp(1.55rem,2.8vw,2.05rem);margin:2.2em 0 .6em}
h3{font-size:1.3rem;margin:1.6em 0 .4em}
p{margin:0 0 1em}
ul,ol{padding-left:1.3em;margin:0 0 1em}
li{margin:.25em 0}
strong{font-weight:700}
.skip{position:absolute;left:-999px;top:0;background:var(--ink);color:#fff;padding:.6em 1em;z-index:100}
.skip:focus{left:1em;top:1em}
.shell{width:min(100% - 2.5rem,var(--maxw));margin-inline:auto}
.narrow{max-width:46rem}

/* ---------- Header ---------- */
.topbar{background:var(--sage-dark);color:#F4EFE6;font-size:.88rem}
.topbar .shell{display:flex;justify-content:space-between;align-items:center;gap:1rem;min-height:40px;flex-wrap:wrap}
.topbar a{color:#fff}
.a11y{display:flex;gap:.35rem;align-items:center}
.a11y span{margin-right:.25rem}
.a11y button{font:inherit;font-size:.85rem;background:transparent;color:#fff;border:1px solid rgba(255,255,255,.45);border-radius:6px;padding:.1em .55em;cursor:pointer;min-width:2.1em}
.a11y button[aria-pressed="true"]{background:#fff;color:var(--sage-dark)}
.site-header{background:var(--surface);border-bottom:1px solid var(--line);position:sticky;top:0;z-index:50}
.header-inner{display:flex;align-items:center;justify-content:space-between;gap:1.5rem;min-height:78px}
.brand{display:flex;align-items:center;gap:.9rem;text-decoration:none;color:var(--ink)}
.brand-mark{display:flex;flex-direction:column;line-height:1.15;white-space:nowrap}
.brand-title{font-family:var(--serif);font-weight:600;font-size:1.6rem;color:var(--ink)}
.brand-title em{font-style:normal;color:var(--sage)}
.brand-sub{font-size:.85rem;color:var(--ink-soft)}
.partner{display:flex;align-items:center;gap:.7rem;text-decoration:none;color:var(--ink-soft);font-size:.82rem;line-height:1.2}
.partner img{height:44px;width:auto}
.partner:hover{color:var(--sage-dark)}
.nav-toggle{display:none;font:inherit;background:var(--sage-light);border:0;border-radius:10px;padding:.55em .9em;color:var(--sage-dark);font-weight:700;cursor:pointer}
.nav-row{border-top:1px solid var(--line);background:var(--surface)}
.primary-nav ul{list-style:none;display:flex;flex-wrap:wrap;gap:.15rem;margin:0;padding:.45rem 0}
.primary-nav a{display:block;padding:.42em .85em;border-radius:999px;text-decoration:none;color:var(--ink);font-size:1rem}
.primary-nav a:hover{background:var(--bg-soft)}
.primary-nav a[aria-current="page"]{background:var(--sage-light);color:var(--sage-dark);font-weight:700}
@media (max-width:980px){
  .nav-toggle{display:inline-flex}
  .partner{display:none}
  .nav-row{border-top:0}
  .primary-nav{width:auto;position:absolute;left:0;right:0;top:100%;background:var(--surface);border-bottom:1px solid var(--line);box-shadow:var(--shadow);display:none}
  .primary-nav.open{display:block}
  .primary-nav ul{flex-direction:column;padding:.8rem 1.25rem 1.2rem}
  .primary-nav a{border-radius:10px;padding:.7em .9em;font-size:1.05rem}
  .primary-nav a.partner-mobile{display:flex}
}
.primary-nav .partner-mobile{display:none;align-items:center;gap:.6rem;padding:.7em .9em;font-size:.9rem;color:var(--ink-soft)}
.partner-mobile img{height:34px;width:auto}
@media (max-width:420px){.topbar .shell>span:first-child{display:none}}

/* ---------- Hero ---------- */
.hero{padding:clamp(2.5rem,6vw,5rem) 0 clamp(2rem,5vw,4rem);background:radial-gradient(1200px 500px at 85% 10%,var(--sage-light),transparent 60%),radial-gradient(900px 400px at 5% 90%,var(--amber-light),transparent 60%)}
.hero-grid{display:grid;grid-template-columns:1.15fr .85fr;gap:3rem;align-items:center}
.eyebrow{display:inline-block;font-size:.88rem;font-weight:700;letter-spacing:.06em;text-transform:uppercase;color:var(--sage-dark);background:var(--sage-light);padding:.3em .8em;border-radius:999px;margin-bottom:.6rem}
.lead{font-size:1.25rem;color:var(--ink-soft);max-width:38rem}
.hero-art{background:var(--surface);border-radius:28px;box-shadow:var(--shadow);padding:1.5rem}
.btns{display:flex;flex-wrap:wrap;gap:.8rem;margin-top:1.6rem}
.btn{display:inline-flex;align-items:center;gap:.5em;padding:.8em 1.3em;border-radius:999px;font-weight:700;text-decoration:none;border:2px solid transparent;font-size:1.02rem}
.btn-primary{background:var(--sage-dark);color:#fff}
.btn-primary:hover{background:var(--ink);color:#fff}
.btn-ghost{border-color:var(--sage);color:var(--sage-dark);background:transparent}
.btn-ghost:hover{background:var(--sage-light);color:var(--sage-dark)}
@media (max-width:860px){.hero-grid{grid-template-columns:1fr}.hero-art{max-width:460px}}

/* ---------- Page header ---------- */
.page-head{padding:clamp(2rem,5vw,3.5rem) 0 1.5rem;background:linear-gradient(180deg,var(--bg-soft),var(--bg))}
.crumbs{font-size:.9rem;color:var(--ink-soft);margin-bottom:.4rem}
.crumbs a{color:var(--ink-soft)}
.page-head .lead{margin-bottom:0}

/* ---------- Layout ---------- */
main{display:block}
.section{padding:clamp(2rem,5vw,3.5rem) 0}
.section-alt{background:var(--surface);border-block:1px solid var(--line)}
.with-toc{display:grid;grid-template-columns:240px 1fr;gap:3rem;align-items:start}
.toc{position:sticky;top:110px;font-size:.95rem;background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.1rem 1.2rem}
.toc strong{display:block;margin-bottom:.4rem;font-family:var(--serif)}
.toc ol{margin:0;padding-left:1.1em}
.toc a{text-decoration:none;color:var(--ink-soft)}
.toc a:hover{color:var(--sage-dark);text-decoration:underline}
@media (max-width:900px){.with-toc{grid-template-columns:1fr}.toc{position:static}}
.content > h2:first-child{margin-top:0}
.content section{scroll-margin-top:110px}

/* ---------- Cards ---------- */
.grid{display:grid;gap:1.25rem}
.grid-3{grid-template-columns:repeat(auto-fit,minmax(300px,1fr))}
.grid-2{grid-template-columns:repeat(auto-fit,minmax(300px,1fr))}
.card{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.4rem 1.5rem;box-shadow:var(--shadow);position:relative}
.card h3{margin-top:.3em;font-size:1.22rem}
.card p:last-child{margin-bottom:0}
a.card{text-decoration:none;color:inherit;transition:transform .15s ease,box-shadow .15s ease;display:block}
a.card:hover{transform:translateY(-2px);box-shadow:0 2px 4px rgba(60,45,25,.06),0 14px 32px rgba(60,45,25,.10)}
a.card .more{color:var(--sage-dark);font-weight:700}
.icon-bubble{width:52px;height:52px;border-radius:14px;display:grid;place-items:center;background:var(--sage-light);color:var(--sage-dark)}
.icon-bubble.blue{background:var(--blue-light);color:var(--blue)}
.icon-bubble.amber{background:var(--amber-light);color:#8A5A08}
.icon-bubble.terra{background:var(--terra-light);color:var(--terra)}
.icon-bubble svg{width:28px;height:28px}

/* ---------- Boxen ---------- */
.glance{background:var(--sage-light);border-radius:var(--radius);padding:1.3rem 1.5rem;margin:0 0 2rem;border:1px solid #CBDDD5}
.glance h2,.glance h3{margin:0 0 .5rem;font-size:1.2rem;display:flex;align-items:center;gap:.5rem}
.glance ul{margin:0}
.merksatz{background:var(--amber-light);border-left:6px solid var(--amber);border-radius:var(--radius-sm);padding:1rem 1.25rem;margin:1.5rem 0}
.merksatz strong:first-child{display:block;color:#7A4E05;margin-bottom:.2rem}
.merksatz p:last-child{margin-bottom:0}
.hinweis{background:var(--blue-light);border-left:6px solid var(--blue);border-radius:var(--radius-sm);padding:1rem 1.25rem;margin:1.5rem 0}
.hinweis p:last-child{margin-bottom:0}
.warn{background:var(--terra-light);border-left:6px solid var(--terra);border-radius:var(--radius-sm);padding:1rem 1.25rem;margin:1.5rem 0}
.warn p:last-child{margin-bottom:0}
.forme{background:var(--surface);border:2px dashed var(--sage);border-radius:var(--radius);padding:1rem 1.25rem;margin:1rem 0 0}
.forme strong:first-child{color:var(--sage-dark)}
.forme p:last-child{margin-bottom:0}

/* ---------- Timeline ---------- */
.timeline{list-style:none;padding:0;margin:1.5rem 0;counter-reset:step;position:relative}
.timeline::before{content:"";position:absolute;left:23px;top:8px;bottom:8px;width:2px;background:var(--line)}
.timeline li{position:relative;padding:0 0 1.6rem 4.2rem;counter-increment:step;margin:0}
.timeline li::before{content:counter(step);position:absolute;left:0;top:0;width:48px;height:48px;border-radius:50%;background:var(--surface);border:2px solid var(--sage);color:var(--sage-dark);font-weight:700;display:grid;place-items:center;font-size:1.1rem}
.timeline h3{margin:.45rem 0 .25rem;font-size:1.18rem}
.timeline .meta{font-size:.9rem;color:var(--ink-soft);font-weight:700}

/* ---------- Tabellen ---------- */
.table-wrap{overflow-x:auto;border:1px solid var(--line);border-radius:var(--radius-sm);background:var(--surface);margin:1rem 0 1.5rem}
table{border-collapse:collapse;width:100%;font-size:1rem}
th,td{text-align:left;padding:.75rem 1rem;border-bottom:1px solid var(--line);vertical-align:top}
thead th{background:var(--sage-dark);color:#fff;font-weight:700}
tbody tr:nth-child(even){background:var(--bg)}
tbody tr:last-child td{border-bottom:0}

/* ---------- Studien ---------- */
.study{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.5rem;margin:0 0 1.5rem;box-shadow:var(--shadow)}
.study h3{margin-top:0}
.tags{display:flex;flex-wrap:wrap;gap:.4rem;margin:.2rem 0 1rem}
.tag{font-size:.82rem;font-weight:700;padding:.2em .7em;border-radius:999px;background:var(--bg-soft);color:var(--ink-soft)}
.tag.green{background:var(--sage-light);color:var(--sage-dark)}
.tag.blue{background:var(--blue-light);color:var(--blue)}
.tag.amber{background:var(--amber-light);color:#7A4E05}
.tag.terra{background:var(--terra-light);color:#7A3B20}
.bars{margin:1rem 0}
.bar-row{display:grid;grid-template-columns:minmax(150px,220px) 1fr;gap:.8rem;align-items:center;margin:.45rem 0;font-size:.95rem}
.bar{height:30px;border-radius:8px;background:var(--bg-soft);position:relative;overflow:hidden}
.bar span{position:absolute;inset:0 auto 0 0;background:var(--sage);border-radius:8px;display:flex;align-items:center;justify-content:flex-end;padding-right:.6rem;color:#fff;font-weight:700;font-size:.9rem;min-width:3.2rem}
.bar.ctrl span{background:#9AA6AF}
@media (max-width:560px){.bar-row{grid-template-columns:1fr}}
.trial-filter{display:flex;flex-wrap:wrap;gap:.5rem;margin:1rem 0 1.5rem}
.trial-filter button{font:inherit;font-size:.95rem;padding:.45em 1em;border-radius:999px;border:1px solid var(--line);background:var(--surface);cursor:pointer;color:var(--ink)}
.trial-filter button[aria-pressed="true"]{background:var(--sage-dark);border-color:var(--sage-dark);color:#fff}
.trial dl{display:grid;grid-template-columns:max-content 1fr;gap:.25rem 1rem;margin:0 0 .8rem;font-size:.98rem}
.trial dt{font-weight:700;color:var(--ink-soft)}
.trial dd{margin:0}

/* ---------- FAQ / Accordion ---------- */
details.acc{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius-sm);margin:.6rem 0;padding:0}
details.acc summary{cursor:pointer;list-style:none;padding:1rem 3rem 1rem 1.2rem;font-weight:700;position:relative}
details.acc summary::-webkit-details-marker{display:none}
details.acc summary::after{content:"+";position:absolute;right:1.1rem;top:50%;transform:translateY(-50%);font-size:1.5rem;color:var(--sage);font-weight:400}
details.acc[open] summary::after{content:"–"}
details.acc[open] summary{border-bottom:1px solid var(--line)}
details.acc .acc-body{padding:1rem 1.2rem .4rem}

/* ---------- Glossar ---------- */
.az{display:flex;flex-wrap:wrap;gap:.3rem;margin:0 0 1.5rem}
.az a{display:grid;place-items:center;width:2.4rem;height:2.4rem;border-radius:8px;background:var(--surface);border:1px solid var(--line);text-decoration:none;font-weight:700;color:var(--sage-dark)}
.az a:hover{background:var(--sage-light)}
.gloss dt{font-weight:700;font-family:var(--serif);font-size:1.15rem;margin-top:1.1rem;scroll-margin-top:110px}
.gloss dd{margin:.2rem 0 0;color:var(--ink)}
.gloss h2{border-bottom:2px solid var(--line);padding-bottom:.2rem}
.search{width:100%;font:inherit;padding:.8rem 1rem;border:2px solid var(--line);border-radius:12px;background:var(--surface);margin-bottom:1rem}
.search:focus{border-color:var(--sage);outline:none}

/* ---------- Untersuchungen ---------- */
.exam{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.6rem;margin:0 0 1.8rem;box-shadow:var(--shadow);scroll-margin-top:110px}
.exam-head{display:flex;gap:1rem;align-items:center;margin-bottom:.6rem}
.exam-head h2{margin:0;font-size:1.6rem}
.facts{display:grid;grid-template-columns:repeat(auto-fit,minmax(170px,1fr));gap:.7rem;margin:1rem 0 1.2rem}
.fact{background:var(--bg);border-radius:12px;padding:.7rem .9rem}
.fact b{display:block;font-size:.82rem;text-transform:uppercase;letter-spacing:.05em;color:var(--ink-soft)}
.fact span{font-weight:700}

/* ---------- Formular ---------- */
.form{display:grid;gap:1rem;max-width:40rem}
.form label{font-weight:700;display:block;margin-bottom:.3rem}
.form input[type=text],.form input[type=email],.form input[type=tel],.form select,.form textarea{width:100%;font:inherit;padding:.75rem .9rem;border:2px solid var(--line);border-radius:10px;background:var(--surface);color:var(--ink)}
.form input:focus,.form textarea:focus,.form select:focus{border-color:var(--sage);outline:none}
.form textarea{min-height:9rem;resize:vertical}
.form .check{display:flex;gap:.7rem;align-items:flex-start;font-weight:400}
.form .check input{width:1.3rem;height:1.3rem;margin-top:.25rem;flex:none}
.form .hp{position:absolute;left:-5000px}
.form button{justify-self:start;cursor:pointer;font:inherit}
.help{font-size:.92rem;color:var(--ink-soft)}
.contact-card{display:grid;gap:.3rem}
.contact-card .big{font-size:1.25rem;font-weight:700}

/* ---------- Footer ---------- */
.site-footer{background:#24343F;color:#E7E1D6;margin-top:3rem;padding:3rem 0 1.5rem;font-size:.98rem}
.site-footer a{color:#fff}
.footer-grid{display:grid;grid-template-columns:1.4fr 1fr 1fr;gap:2.5rem}
.site-footer h2{color:#fff;font-size:1.1rem;margin:0 0 .7rem}
.site-footer ul{list-style:none;padding:0;margin:0}
.site-footer li{margin:.35rem 0}
.footer-brand img{background:#FFFDF9;border-radius:10px;padding:8px 12px;height:56px;width:auto}
.footer-bottom{border-top:1px solid rgba(255,255,255,.15);margin-top:2rem;padding-top:1.2rem;display:flex;flex-wrap:wrap;justify-content:space-between;gap:1rem;font-size:.88rem;color:#C9C2B6}
.disclaimer{font-size:.9rem;color:#C9C2B6;margin-top:1rem}
@media (max-width:820px){.footer-grid{grid-template-columns:1fr}}

/* ---------- Diverses ---------- */
.stand{font-size:.9rem;color:var(--ink-soft);margin-top:-.5rem}
.figure{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.2rem;margin:1.5rem 0}
.figure figcaption{font-size:.92rem;color:var(--ink-soft);margin-top:.6rem}
.two-col{display:grid;grid-template-columns:1fr 1fr;gap:2rem;align-items:center}
@media (max-width:820px){.two-col{grid-template-columns:1fr}}
.cta{background:var(--sage-dark);color:#F4EFE6;border-radius:24px;padding:clamp(1.5rem,4vw,2.5rem);display:grid;grid-template-columns:1fr auto;gap:1.5rem;align-items:center}
.cta h2{color:#fff;margin:0 0 .3rem}
.cta p{margin:0}
.cta .btn-primary{background:#fff;color:var(--sage-dark)}
.cta .btn-primary:hover{background:var(--amber-light)}
@media (max-width:700px){.cta{grid-template-columns:1fr}}
.backtop{display:inline-block;margin-top:.5rem;font-size:.9rem}
.notice{background:var(--surface);border:1px solid var(--line);border-radius:var(--radius);padding:1.5rem;text-align:center}
.print-only{display:none}
@media print{
  .topbar,.site-header,.site-footer,.toc,.btns,.trial-filter,.nav-toggle,.backtop,.no-print{display:none!important}
  body{background:#fff;font-size:12pt}
  .card,.study,.exam{box-shadow:none;break-inside:avoid}
  .print-only{display:block}
  a{color:#000}
}

/* ---------- Mobile-Feinschliff ---------- */
.with-toc>*,.grid>*,.two-col>*,.hero-grid>*,.footer-grid>*{min-width:0}
h1,h2,h3{hyphens:auto;-webkit-hyphens:auto;overflow-wrap:break-word}
.content p,.content li,.content dd,.card p{hyphens:auto;-webkit-hyphens:auto}
.grid-2{grid-template-columns:repeat(auto-fit,minmax(min(300px,100%),1fr))}
.grid-3{grid-template-columns:repeat(auto-fit,minmax(min(300px,100%),1fr))}
@media (max-width:560px){
  .header-inner{gap:.75rem;min-height:68px}
  .brand-title{font-size:1.3rem}
  .brand-sub{font-size:.75rem}
  .nav-toggle{padding:.5em .75em;font-size:.95rem}
  .trial dl{grid-template-columns:1fr}
  .trial dd{margin-bottom:.4rem}
  .exam{padding:1.2rem}
  .exam-head{align-items:flex-start}
  .card{padding:1.2rem}
  .timeline li{padding-left:3.6rem}
}
.contact-card>*{min-width:0}.contact-card a{overflow-wrap:anywhere}